Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy

PR Prestes; FZ Marques; G Lopez-Campos; P Lewandowski; LMD Delbridge; FJ Charchar; SB Harrap

Journal article

Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy

PR Prestes, FZ Marques, G Lopez-Campos, P Lewandowski, LMD Delbridge, FJ Charchar, SB Harrap

Physiological Genomics | AMER PHYSIOLOGICAL SOC | Published : 2018

DOI: 10.1152/physiolgenomics.00143.2017

Abstract

Hypertrophic cardiomyopathy thickens heart muscles, reducing functionality and increasing risk of cardiac disease and morbidity. Genetic factors are involved, but their contribution is poorly understood. We used the hypertrophic heart rat (HHR), a unique normotensive polygenic model of cardiac hypertrophy and heart failure, to investigate the role of genes associated with monogenic human cardiomyopathy. We selected 42 genes involved in monogenic human cardiomyopathies to study: 1) DNA variants, by sequencing the whole genome of 13-wk-old HHR and age-matched normal heart rat (NHR), its genetic control strain; 2) mRNA expression, by targeted RNA-sequencing in left ventricles of HHR and NHR at ..

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University of Melbourne Researchers

Lea Delbridge Author

Stephen Harrap Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health & Medical Research Council of Australia (Project Grant APP1034371, APP509252), the National Heart Foundation (Project Grant G10M5155, GM6368), and the Federation University Australia "Self-sustaining Regions Research and Innovation Initiative," an Australian Government Collaborative Research Network. F. Marques is supported by National Heart Foundation Future Leader and Baker co-shared Fellowships. P. Prestes is supported by a Federation University Australia Robert HT Smith Fellowship.